The lysosome plays a pivotal role between catabolic and anabolic processes as the nexus
for signalling pathways responsive to a variety of factors, such as growth, nutrient availability, …

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that affect
people of all ages and ethnicities but are most prevalent in children. Commonly known as …

Background: The initial stages of phagocytosis and cell motility resemble each other. The
extension of a pseudopod at the leading edge of a migratory cell and the formation of a …

The family of unconventional myosins is ever growing and the functions attributed to them
seem to expand in parallel. These actin‐based motor proteins have been implicated in …

RasG is the most abundant Ras protein in growing Dictyostelium cells and the closest relative
of mammalian Ras proteins. We have generated null mutants in which expression of RasG …

Mutations in the CLN3 gene cause juvenile neuronal ceroid lipofuscinosis (JNCL or Batten
disease), an early onset neurodegenerative disorder. JNCL is the most common of the NCLs, …

DNA double-strand breaks occur in many acute and long-term neurological conditions,
including neurodegeneration, neurotrauma, and stroke. Nonrepaired breaks chronically activate …

Mutations in the gene CLN3 are responsible for the neurodegenerative disorder juvenile
neuronal ceroid lipofuscinosis or Batten disease. CLN3 encodes a multi-spanning and …

The neuronal ceroid lipofuscinoses are a group of severe and progressive neurodegenerative
disorders, generally with childhood onset. Despite the fact that these diseases remain fatal…

DNA double-strand breaks are a feature of many acute and long-term neurological disorders,
including neurodegeneration, following neurotrauma and after stroke. Persistent activation …