2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse
range of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

While the oxygen-dependent reversal of lysine N ɛ -methylation is well established, the
existence of bona fide N ω -methylarginine demethylases (RDMs) is controversial. Lysine …

The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II)-dependent
oxygenases. KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze …

N-Methylation of lysine and arginine residues has emerged as a major mechanism of
transcriptional regulation in eukaryotes. In humans, N ε -methyllysine residue demethylation is …

The discovery that protein and nucleic acid demethylation is common opens up the
possibility of ‘methylation cycles’ of functional importance, including in the regulation of gene …

There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with
small molecules both for the generation of probes for target exploration and for therapeutic …

Crop yield loss due to flooding is a threat to food security. Submergence-induced hypoxia in
plants results in stabilization of group VII ETHYLENE RESPONSE FACTORs (ERF-VIIs), …

2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases.
Using a representative 2OG oxygenase panel, we compare the inhibitory activities of 5-…

Organisms must respond to hypoxia to preserve oxygen homeostasis. We identify a thiol
oxidase, previously assigned as cysteamine (2-aminoethanethiol) dioxygenase (ADO), as a low …

The JmjC oxygenases catalyze the N-demethylation of N ε -methyl lysine residues in
histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were …