A blood-based protein biomarker, or set of protein biomarkers, that could predict onset and
progression of Alzheimer’s disease (AD) would have great utility; potentially clinically, but …

Much of the knowledge and information needed for enabling high-quality clinical research
is stored in free-text format. Natural language processing (NLP) has been used to extract …

Many common diseases are accompanied by disturbances in biochemical traits. Identifying
the genetic determinants could provide novel insights into disease mechanisms and reveal …

Background In the absence of a vaccine or effective treatment for COVID-19, countries have
adopted nonpharmaceutical interventions (NPIs) such as social distancing and full lockdown…

The number of people affected by mental illness is on the increase and with it the burden on
health and social care use, as well as the loss of both productivity and quality-adjusted life-…

Blood proteins and their complexes have become the focus of a great deal of interest in the
context of their potential as biomarkers of Alzheimer's disease (AD). We used a SOMAscan …

Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies
have identified 47 distinct genetic variants robustly associated with BP, but collectively …

Background The National Early Warning Score (NEWS2) is currently recommended in the
UK for the risk stratification of COVID-19 patients, but little is known about its ability to detect …

Background Serum uric acid levels in humans are influenced by diet, cellular breakdown,
and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, …

Aims The SARS‐CoV‐2 virus binds to the angiotensin‐converting enzyme 2 (ACE2)
receptor for cell entry. It has been suggested that angiotensin‐converting enzyme inhibitors (ACEi) …