User profiles for Richard McLaughlin

Richard N. McLaughlin Jr.

Pacific Northwest Research Institute
Verified email at pnri.org
Cited by 1180

Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery

…, D Weinreich, D Goia, N Pavel, RE McLaughlin… - Drug …, 2004 - Taylor & Francis
Colloidal gold, a sol comprised of nanoparticles of Au 0 , has been used as a therapeutic for
the treatment of cancer as well as an indicator for immunodiagnostics. However, the use of …

The spatial architecture of protein function and adaptation

RN McLaughlin Jr, FJ Poelwijk, A Raman, WS Gosal… - Nature, 2012 - nature.com
Statistical analysis of protein evolution suggests a design for natural proteins in which
sparse networks of coevolving amino acids (termed sectors) comprise the essence of three-…

Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

Y Zhang, R McLaughlin, C Goodyer… - The Journal of cell …, 2002 - rupress.org
Extracellular amyloid β peptides (Aβs) have long been thought to be a primary cause of
Alzheimer's disease (AD). Now, detection of intracellular neuronal Aβ 1–42 accumulation before …

Microbial hyaluronic acid production

BF Chong, LM Blank, R Mclaughlin… - Applied microbiology and …, 2005 - Springer
Abstracts Hyaluronic acid (HA) is a commercially valuable medical biopolymer increasingly
produced through microbial fermentation. Viscosity limits product yield and the focus of …

[HTML][HTML] Hot spots for allosteric regulation on protein surfaces

KA Reynolds, RN McLaughlin, R Ranganathan - Cell, 2011 - cell.com
Recent work indicates a general architecture for proteins in which sparse networks of physically
contiguous and coevolving amino acids underlie basic aspects of structure and function. …

Automated debug of speed path failures using functional tests

R McLaughlin, S Venkataraman… - 2009 27th IEEE VLSI Test …, 2009 - ieeexplore.ieee.org
Debug of at-speed failures using functional tests is a key challenge as part of frequency
pushes during post-silicon debug to improve performance of high performance designs, …

A comparative study of Caucasian and Japanese mandibular clinical arch forms

K Nojima, RP McLaughlin, Y Isshiki… - The Angle …, 2001 - meridian.allenpress.com
The purpose of this study was to clarify morphological differences between Caucasian and
Japanese mandibular clinical arch forms in Class I, II, and III malocclusions. The study …

[HTML][HTML] The effects of compost incorporation on soil physical properties in urban soils–A concise review

CN Kranz, RA McLaughlin, A Johnson, G Miller… - Journal of …, 2020 - Elsevier
Incorporation of compost into soil can significantly alter soil physical properties, nutrient
dynamics, and vegetation establishment. Strategic compost application to disturbed, degraded …

Comparison of arch forms between Korean and North American white populations

YA Kook, K Nojima, HB Moon, RP McLaughlin… - American journal of …, 2004 - Elsevier
The purpose of this study was to evaluate morphologic differences in the mandibular arches
of Korean and North American white subjects. The subjects were grouped according to arch …

Are there naturally occurring pleomorphic bacteria in the blood of healthy humans?

RW McLaughlin, H Vali, PCK Lau… - Journal of clinical …, 2002 - Am Soc Microbiol
Dark-field microscopy of blood from healthy individuals revealed the existence of pleomorphic
microorganisms. These bacteria exhibited limited growth and susceptibility to antibiotics …