User profiles for Richard McLaughlin
Richard N. McLaughlin Jr.Pacific Northwest Research Institute Verified email at pnri.org Cited by 1180 |
Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery
…, D Weinreich, D Goia, N Pavel, RE McLaughlin… - Drug …, 2004 - Taylor & Francis
Colloidal gold, a sol comprised of nanoparticles of Au 0 , has been used as a therapeutic for
the treatment of cancer as well as an indicator for immunodiagnostics. However, the use of …
the treatment of cancer as well as an indicator for immunodiagnostics. However, the use of …
The spatial architecture of protein function and adaptation
RN McLaughlin Jr, FJ Poelwijk, A Raman, WS Gosal… - Nature, 2012 - nature.com
Statistical analysis of protein evolution suggests a design for natural proteins in which
sparse networks of coevolving amino acids (termed sectors) comprise the essence of three-…
sparse networks of coevolving amino acids (termed sectors) comprise the essence of three-…
Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons
Y Zhang, R McLaughlin, C Goodyer… - The Journal of cell …, 2002 - rupress.org
Extracellular amyloid β peptides (Aβs) have long been thought to be a primary cause of
Alzheimer's disease (AD). Now, detection of intracellular neuronal Aβ 1–42 accumulation before …
Alzheimer's disease (AD). Now, detection of intracellular neuronal Aβ 1–42 accumulation before …
Microbial hyaluronic acid production
BF Chong, LM Blank, R Mclaughlin… - Applied microbiology and …, 2005 - Springer
Abstracts Hyaluronic acid (HA) is a commercially valuable medical biopolymer increasingly
produced through microbial fermentation. Viscosity limits product yield and the focus of …
produced through microbial fermentation. Viscosity limits product yield and the focus of …
[HTML][HTML] Hot spots for allosteric regulation on protein surfaces
Recent work indicates a general architecture for proteins in which sparse networks of physically
contiguous and coevolving amino acids underlie basic aspects of structure and function. …
contiguous and coevolving amino acids underlie basic aspects of structure and function. …
Automated debug of speed path failures using functional tests
R McLaughlin, S Venkataraman… - 2009 27th IEEE VLSI Test …, 2009 - ieeexplore.ieee.org
Debug of at-speed failures using functional tests is a key challenge as part of frequency
pushes during post-silicon debug to improve performance of high performance designs, …
pushes during post-silicon debug to improve performance of high performance designs, …
A comparative study of Caucasian and Japanese mandibular clinical arch forms
K Nojima, RP McLaughlin, Y Isshiki… - The Angle …, 2001 - meridian.allenpress.com
The purpose of this study was to clarify morphological differences between Caucasian and
Japanese mandibular clinical arch forms in Class I, II, and III malocclusions. The study …
Japanese mandibular clinical arch forms in Class I, II, and III malocclusions. The study …
[HTML][HTML] The effects of compost incorporation on soil physical properties in urban soils–A concise review
Incorporation of compost into soil can significantly alter soil physical properties, nutrient
dynamics, and vegetation establishment. Strategic compost application to disturbed, degraded …
dynamics, and vegetation establishment. Strategic compost application to disturbed, degraded …
Comparison of arch forms between Korean and North American white populations
YA Kook, K Nojima, HB Moon, RP McLaughlin… - American journal of …, 2004 - Elsevier
The purpose of this study was to evaluate morphologic differences in the mandibular arches
of Korean and North American white subjects. The subjects were grouped according to arch …
of Korean and North American white subjects. The subjects were grouped according to arch …
Are there naturally occurring pleomorphic bacteria in the blood of healthy humans?
RW McLaughlin, H Vali, PCK Lau… - Journal of clinical …, 2002 - Am Soc Microbiol
Dark-field microscopy of blood from healthy individuals revealed the existence of pleomorphic
microorganisms. These bacteria exhibited limited growth and susceptibility to antibiotics …
microorganisms. These bacteria exhibited limited growth and susceptibility to antibiotics …