Background The diverse cellular constituents of childhood brain tumor ependymoma, recently
revealed by single cell RNA-sequencing, may underly therapeutic resistance. Here we …

Childhood ependymoma (EPN) is a brain tumor that has seen limited improvements in
outcome over past decades. The underlying cellular components of EPN have recently been …

… © 2020 Peter Grundy The right of Peter Grundy to be identified as author of this work has …
Sadly, we won’t be examining humour in this book, but it’s certainly a rich field to investigate …

Class Ib genes constitute the majority of MHC class I loci. These monoн morphic or oligomorphic
molecules have been described in many organisms; they are best characterized in the …

Understanding the biology that underlies histologically similar but molecularly distinct
subgroups of cancer has proven difficult because their defining genetic alterations are often …

Background Over half of childhood intracranial ependymomas occur in children younger
than 5 years. As an adjuvant treatment, radiotherapy can be effective, but has the potential to …

Background Suspicion of a CNS tumour is classically raised by symptoms of raised intracranial
pressure, focal deficits (including seizures), or papilloedema. Development of guidelines …

… As we have been discussing, binding responses are information rich, much of which is
apparent even before model fitting. For example, with a little practice you can estimate …

Background. Gliomas of the hypothalamus and optic pathways (H/OPG) comprise 5% of
pediatric intracranial tumors, present most frequently in patients younger than age 5 years, and …

Background Histopathological grading of ependymoma has been controversial with respect
to its reproducibility and clinical significance. In a 3-phase study, we reviewed the pathology …