The recognition of specific DNA sequences by proteins is thought to depend on two types of
mechanism: one that involves the formation of hydrogen bonds with specific bases, primarily …

Specific interactions between proteins and DNA are fundamental to many biological processes.
In this review, we provide a revised view of protein-DNA interactions that emphasizes …

We report a three-dimensional microscopy technique—swept, confocally-aligned planar
excitation (SCAPE) microscopy—that allows volumetric imaging of living samples at ultrahigh …

Members of transcription factor families typically have similar DNA binding specificities yet
execute unique functions in vivo. Transcription factors often bind DNA as multiprotein …

For many DNA-binding transcription factors it is often difficult to reconcile their highly specific
in vivo functions with their less specific in vitro DNA-binding properties. Cooperative DNA …

Female Aedes aegypti mosquitoes infect more than 400 million people each year with
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in …

We show that homothorax (hth) is required for the Hox genes to pattern the body of the fruit
fly, Drosophila melanogaster. hth is necessary for the nuclear localization of an essential …

The Hox genes are clustered sets of homeobox-containing genes that play a central role in
animal development. Recent genetic and molecular data suggest that Hox proteins interact …

Comparison of Hoxb-1 regulatory regions from different vertebrates identified three related
sequence motifs critical for rhombomere 4 (r4) expression in the hindbrain. Functional …

The recognition of specific DNA-binding sites by transcription factors is a critical yet poorly
understood step in the control of gene expression. Members of the Hox family of transcription …