… A key region involved in STIM1 redistribution is the polybasic domain (PBD), a lysine-rich
stretch of 15 residues at the extreme COOH terminus (Figure 2). Deletion of the PBD prevents …

Store-operated Ca 2+ channels activated by the depletion of Ca 2+ from the endoplasmic
reticulum (ER) are a major Ca 2+ entry pathway in nonexcitable cells and are essential for T …

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology
and serves as a model system for the investigation of many developmental and cellular …

Antigen stimulation of immune cells triggers Ca 2+ entry through Ca 2+ release-activated
Ca 2+ (CRAC) channels, promoting the immune response to pathogens by activating the …

Cytosolic calcium ([Ca 2+ ] i ) oscillations are a nearly universal mode of signalling in excitable
and non-excitable cells 1 , 2 , 3 , 4 . Although Ca 2+ is known to mediate a diverse array …

An increase in the intracellular calcium ion concentration ([Ca 2+ ] i ) controls a diverse
range of cell functions, including adhesion, motility, gene expression and proliferation 1,2 . …

… Analyzing gene-expression patterns by in situ hybridization to whole-mount embryos
provides an extremely rich dataset that can be used to identify genes involved in developmental …

The results described herein support a mechanistic hypothesis for how guanidine-rich
transporters attached to small cargos (MW ca. <3000) can migrate across the lipid membrane of a …

Elevation of intracellular free Ca 2+ is one of the key triggering signals for T-cell activation by
antigen. A remarkable variety of Ca 2+ signals in T cells, ranging from infrequent spikes to …

Stimulated influx of Ca2+ across the plasma membrane of T lymphocytes is an essential
triggering signal for T-cell activation by antigen. Regulation of the T-cell Ca2+ conductance is …