Although recent studies have revealed that heart cells are generated in adult mammals, the
frequency of generation and the source of new heart cells are not yet known. Some studies …

Heart failure is the leading cause of death worldwide, and current therapies only delay
progression of the disease. Laboratory experiments and recent clinical trials suggest that cell-…

Mutations in the lamin A/C gene (LMNA) cause a variety of human diseases including Emery-Dreifuss
muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria …

ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2)
isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels predict …

The most common form of heart failure occurs with normal systolic function and often involves
cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac …

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural
stem cell behavior by providing circulating and secreted factors. Age-related decline of …

BACKGROUND Although rupture of an atherosclerotic plaque is considered to be the cause
of most acute coronary syndromes, the mechanism of plaque rupture is controversial. …

Matrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial infarction
(MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less left …

Inflammation plays an important role in the development of atherosclerosis, but the specific
stimuli governing cytokine release in atherogenesis are unknown. We examined the …

Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner,
yet little is known about their roles in lineage commitment. Here, we identified Braveheart (Bvht…