Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion
cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich …

The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells
and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully …

Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest
stages of this complex disease are still unclear. This study was specifically designed to …

Using a variety of double and triple labeling techniques, we have reevaluated the death of
retinal neurons in a mouse model of hereditary glaucoma. Cell-specific markers and total …

In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It
is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the …

Components of the extracellular matrix exert myriad effects on tissues throughout the body.
In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, have been …

Glaucoma is a common neurodegenerative disease that affects retinal ganglion cells (RGCs).
Substantial effort is being expended to determine how RGCs die in glaucoma. As in other …

Mutations in the cytochrome P450 family 1, subfamily B, polypeptide 1 (CYP1B1) gene are a
common cause of human primary congenital glaucoma (PCG). Here we show thatCyp1b1 –/…

Glaucoma is a common ocular disorder that is a leading cause of blindness worldwide. It is
characterized by the dysfunction and loss of retinal ganglion cells (RGCs). Although many …

Purpose.: Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in
transducing inner retinal neurons after intravitreal injection in several species. However, results …