… Caveolae are flask-shaped membrane invaginations that are rich in caveolin proteins as
well as cholesterol. The mechanisms by which 7TM receptors are targeted to caveolae are not …

▪ Abstract G protein–coupled receptors (GPCRs) have proven to be the most highly favorable
class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are …

Physiological effects of β adrenergic receptor (β2AR) stimulation have been classically shown
to result from G s -dependent adenylyl cyclase activation. Here we demonstrate a novel …

Stimulation of β 2 -adrenergic receptors on the cell surface by adrenaline or noradrenaline
leads to alterations in the metabolism, excitability, differentiation and growth of many cell types…

G protein‐coupled receptor kinases (GRKs) are a family of serine/threonine protein kinases
that specifically recognize agonist‐occupied, activated G protein‐coupled receptor proteins …

Heterotrimeric G protein–coupled receptors (GPCRs) are found on the surface of all cells of
multicellular organisms and are major mediators of intercellular communication. More than …

Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal
lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (…

The Na + /H + exchanger regulatory factor (NHERF) binds to the tail of the β 2 -adrenergic
receptor and plays a role in adrenergic regulation of Na + /H + exchange. NHERF contains …

Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of
people worldwide. However recent studies have indicated that niclosamide may have broad …

Lymphocyte chemotaxis is a complex process by which cells move within tissues and across
barriers such as vascular endothelium and is usually stimulated by chemokines such as …