INTRODUCTION New therapies have been designed to stimulate the host’s immune system
to fight cancer. Despite these exciting, recent successes, a large proportion of patients still …

The nature of the psychological processes that underlie the Gestalt principles of grouping
by proximity and grouping by similarity is examined. Similarity was defined relative to the …

DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …

When computing alignments of DNA sequences to a large genome, a key element in
achieving high processing throughput is to prioritize locations in the genome where high-scoring …

Data intensive computing presents a significant challenge for traditional supercomputing
architectures that maximize FLOPS since CPU speed has surpassed IO capabilities of HPC …

Over the past decade, short-read sequence alignment has become a mature technology.
Optimized algorithms, careful software engineering and high-speed hardware have contributed …

Antipsychotic drugs are the current first-line of treatment for schizophrenia and other psychotic
conditions. However, their molecular effects on the human brain are poorly studied, due to …

Motivation Read alignment is an essential first step in the characterization of DNA sequence
variation. The accuracy of variant-calling results depends not only on the quality of read …

Objective. To evaluate the accuracy of immunization records transcribed into a computer-based
immunization tracking system and to assess factors that contribute to inaccurate or …

Motivation The alignment of bisulfite-treated DNA sequences (BS-seq reads) to a large
genome involves a significant computational burden beyond that required to align non-bisulfite-…