In recent years a substantial number of findings have been made in the area of immunometabolism,
by which we mean the changes in intracellular metabolic pathways in immune cells …

Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based
immunotherapies. Here we perturbed genes in human melanoma cells to mimic loss-of-function …

Activation of CD4 + T cells results in rapid proliferation and differentiation into effector and
regulatory subsets. CD4 + effector T cell (Teff) (Th1 and Th17) and Treg subsets are …

Activated T cells differentiate into functional subsets with distinct metabolic programs.
Glutaminase (GLS) converts glutamine to glutamate to support the tricarboxylic acid cycle and …

CD4 + effector T cells (T eff cells) and regulatory T cells (T reg cells) undergo metabolic
reprogramming to support proliferation and immunological function. Although signaling via the …

Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …

INTRODUCTION Cancers persist and progress despite the presence of tumor-infiltrating
lymphocytes (TILs). A paradox of tumor immunology is that tumor antigen–specific TILs are …

Follicular helper T (Tfh) cells are crucial for germinal center (GC) formation and humoral
adaptive immunity. Mechanisms underlying Tfh cell differentiation in peripheral and mucosal …

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with
Notch pathway mutations. While both normal activated and leukemic T cells can utilize aerobic …

Stimulating an immune response against cancer through adoptive transfer of tumor-targeting
lymphocytes has shown great promise in hematological malignancies, but clinical efficacy …