Aims More intense platelet-directed therapy for acute coronary syndrome (ACS) may increase
bleeding risk. The aim of the current analysis was to determine the rate, clinical impact, …

VEGF-C is a recently characterised endothelial growth factor structurally related to vascular
endothelial growth factor (VEGF). We studied the expression of VEGF-C and VEGF in the …

As the management of haemophilia is complex, it is essential that those with the disorder
should have ready access to a range of services provided by a multidisciplinary team of …

Background Patients with severe hemophilia A and factor VIII inhibitors are at increased risk
for serious bleeding complications and progression to end-stage joint disease. Effective …

Insulin resistance is associated with an increased risk of atherothrombotic vascular disease,
but the mechanisms are poorly understood. We determined how insulin in vivo regulates …

Platelet-derived microparticles (MP) are reported to express both pro- and anticoagulant
activities. Nevertheless, their functional significance has remained unresolved. The present …

Coagulation and fibrinolytic activities are under strong genetic control. We studied the effects
of acquired obesity, independent of genetic factors on coagulation and fibrinolysis activities …

Object. From the moment an intracranial aneurysm ruptures, cerebral blood flow is impaired,
and this impairment mainly determines the outcome in patients who survive after the initial …

Background and aims: Obesity and the metabolic syndrome are established risk factors of
venous thromboembolism. As most coagulation factors are produced exclusively by the liver …

The antiplatelet effect of aspirin varies individually. This study evaluated whether the
antiplatelet effect of aspirin associates with polymorphisms in the genes coding for cyclo-oxygenase…