THE relationship between the semantic processing of words and of pictures is a matter of
debate among cognitive scientists 1,2 . We studied the functional anatomy of such processing …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

This article provides a classification of primary progressive aphasia (PPA) and its 3 main
variants to improve the uniformity of case reporting and the reliability of research results. …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Frontotemporal dementia (FTD) with ubiquitin-immunoreactive neuronal inclusions (both
cytoplasmic and nuclear) of unknown nature has been linked to a chromosome 17q21 region (…

Importance Amyloid-β positron emission tomography (PET) imaging allows in vivo detection
of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its …

Background Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)
are extremes of a clinically, pathologically, and genetically overlapping disease spectrum…

Objective The most widely studied positron emission tomography ligand for in vivo β‐amyloid
imaging is 11 C‐Pittsburgh compound B ( 11 C‐PIB). Its availability, however, is limited by …

Background Alzheimer’s disease is characterized by the deposition of amyloid-beta (Aβ)
plaques in the brain. Aβ is produced from the sequential cleavage of amyloid precursor protein …

This PET study has revealed the neural system involved in implicit face, proper-name and
object name processing during an explicit visual 'same' versus 'different' matching task. Within …