The N 6 -methylation of internal adenosines (m6A) in mRNA has been quantified and localized
throughout the transcriptome. However, the physiological significance of m6A in most …

Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately
associated with dynamic chromatin remodeling. However, how cellular metabolism directs …

The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation
of nuclei acids and proteins, regulating all aspects of cellular physiology. We have …

Glycyrrhizae Radix is the most frequently used crude drug in Japan and is prescribed in
Kampo medicine for the treatment of a wide range of diseases. The major active ingredient of …

With the current societal norm of shiftwork and long working hours, maintaining a stable daily
life is becoming very difficult. An irregular lifestyle disrupts circadian rhythms, resulting in …

Mutations in the GBA1 gene increase the risk of developing Parkinson’s disease (PD).
However, most carriers of GBA1 mutations do not develop PD throughout their lives. The …

Schizophrenia (SZ) and bipolar disorder (BD), which are both psychiatric disorders, share
some common clinical evidence. We recently discovered that brain capillary angiopathy is …

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder
affecting over 1% of the 65 + age population. Saposin C, a lysosomal protein required for …

Purpose: We describe a poorly differentiated adenocarcinoma of the lung in an 11-year-old
boy who had had a pulmonary hamartoma for at least 8 years. Conclusions: A hamartoma …

A number of genetic variants have been linked to Parkinson’s disease (PD). Among these,
mutations in the GBA1 gene are identified as one of the most common risk factors for …