Crystal structure of p-hydroxybenzoate hydroxylase
RK Wierenga, RJ De Jong, KH Kalk, WGJ Hol… - Journal of molecular …, 1979 - Elsevier
The structure of the enzyme p-hydroxybenzoate hydroxylase (EC 1.14.13.2) in a complex with
its substrate has been determined at a resolution of 2.5 Å. The molecular weight is 43,000 …
its substrate has been determined at a resolution of 2.5 Å. The molecular weight is 43,000 …
Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl‐CoA thiolase (T2) deficiency
…, RK Harijan, S Yamaguchi, RK Wierenga… - Human …, 2019 - Wiley Online Library
Mitochondrial acetoacetyl‐CoA thiolase (T2, encoded by the ACAT1 gene) deficiency is an
inherited disorder of ketone body and isoleucine metabolism. It typically manifests with …
inherited disorder of ketone body and isoleucine metabolism. It typically manifests with …
[HTML][HTML] A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community)
…, JM Thornton, P Tuffery, G Tusnady, R Wierenga… - …, 2020 - ncbi.nlm.nih.gov
Structural bioinformatics provides the scientific methods and tools to analyse, archive,
validate, and present the biomolecular structure data generated by the structural biology …
validate, and present the biomolecular structure data generated by the structural biology …
[HTML][HTML] Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps
Triosephosphate isomerase (TIM) is a key enzyme in glycolysis that catalyses the
interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. This simple …
interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. This simple …
Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics
…, S Sridhar, TR Kiema, RK Wierenga… - The FEBS …, 2023 - Wiley Online Library
A group‐III iron containing 1,2‐propanediol oxidoreductase, FucO, (also known as
lactaldehyde reductase) from Escherichia coli was examined regarding its structure–dynamics–…
lactaldehyde reductase) from Escherichia coli was examined regarding its structure–dynamics–…
Development of MLPA for human ACAT1 gene and identification of a heterozygous Alu-mediated deletion of exons 3 and 4 in a patient with mitochondrial acetoacetyl …
…, K Murase, T Hori, RK Harijan, RK Wierenga… - Molecular genetics and …, 2013 - Elsevier
Mitochondrial acetoacetyl-CoA thiolase deficiency is an autosomal recessive disorder,
characterized by intermittent ketoacidosis. We developed a multiplex ligation-dependent probe …
characterized by intermittent ketoacidosis. We developed a multiplex ligation-dependent probe …
Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and …
…, U Bergmann, TR Kiema, RK Wierenga - … Section D: Structural …, 2020 - scripts.iucr.org
The peroxisomal multifunctional enzyme type 1 (MFE1) catalyzes two successive reactions
in the β-oxidation cycle: the 2E-enoyl-CoA hydratase (ECH) and NAD+-dependent 3S-…
in the β-oxidation cycle: the 2E-enoyl-CoA hydratase (ECH) and NAD+-dependent 3S-…
[HTML][HTML] Crystal Structure of a Monomeric Thiolase-Like Protein Type 1 (TLP1) from Mycobacterium smegmatis
N Janardan, RK Harijan, RK Wierenga, MRN Murthy - 2012 - journals.plos.org
An analysis of the Mycobacterium smegmatis genome suggests that it codes for several
thiolases and thiolase-like proteins. Thiolases are an important family of enzymes that are …
thiolases and thiolase-like proteins. Thiolases are an important family of enzymes that are …
Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis
…, RK Harijan, TR Kiema, RK Wierenga… - … Section D: Biological …, 2015 - scripts.iucr.org
Thiolases catalyze the degradation and synthesis of 3-ketoacyl-CoA molecules. Here, the
crystal structures of a T1-like thiolase (MSM-13 thiolase) from Mycobacterium smegmatis in …
crystal structures of a T1-like thiolase (MSM-13 thiolase) from Mycobacterium smegmatis in …
A Master of Science course on macromolecular X-ray crystallography resembling a realistic research project
…, E Daniel, E Obaji, R Venkatesan, RK Wierenga… - 2023 - osf.io
Macromolecular X-ray crystallography is a robust method to understand protein functions at
the molecular level, deciphering their various roles in biochemical processes. This makes …
the molecular level, deciphering their various roles in biochemical processes. This makes …