A functioning gene drive system could fundamentally change our strategies for the control of
vector-borne diseases by facilitating rapid dissemination of transgenes that prevent …

CRISPR homing gene drives can convert heterozygous cells with one copy of the drive
allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism …

Gene drives could allow for control of vector-borne diseases by directly suppressing vector
populations or spreading genetic payloads designed to reduce pathogen transmission. …

Estimating fitness differences between allelic variants is a central goal of experimental
evolution. Current methods for inferring such differences from allele frequency time series …

Gene drives could allow for control of vector-borne diseases by directly suppressing vector
populations or spreading genetic payloads designed to reduce pathogen transmission. …

CRISPR gene drives can efficiently convert heterozygous cells with one copy of the drive allele
into homozygotes, thereby enabling super-Mendelian inheritance. This mechanism could …

Importance The longer-term effects of therapies for the treatment of critically ill patients with
COVID-19 are unknown. Objective To determine the effect of multiple interventions for …

Given the potential impact of climate change on amphibians, there is a need to establish
baseline phenological data for vulnerable species and to investigate their responses to …

Importance The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain.
Objective To determine whether antiplatelet therapy improves outcomes for critically ill …

Allotetraploid emmer wheat. Emmer contains the A and B subgenomes of einkorn and an
extinct Aegilops species. While this species is still cultivated today in limited quantities, its …