Background : Sudden arrhythmic death syndrome (SADS) describes a sudden death with
negative autopsy and toxicological analysis. Cardiac genetic disease is a likely etiology. …

Background: Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative
drug exposures and preexisting cardiovascular disorders. These parameters incompletely …

Background : Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left
ventricle due to chronic excess alcohol consumption. It is largely unknown which factors …

Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100
purported disease genes tested in clinical laboratories. However, many genes were originally …

BackgroundClozapine, an antipsychotic with unique efficacy in treatment-resistant psychosis,
is associated with increased susceptibility to infection, including pneumonia.AimsTo …

Background International guidelines for variant interpretation in Mendelian disease set stringent
criteria to report a variant as (likely) pathogenic, prioritising control of false-positive rate …

Background : Improved understanding of dilated cardiomyopathy (DCM) due to titin truncation
(TTNtv) may help guide patient stratification. Objectives : The purpose of this study was to …

Purpose Internationally adopted variant interpretation guidelines from the American College
of Medical Genetics and Genomics (ACMG) are generic and require disease-specific …

Purpose Accurate discrimination of benign and pathogenic rare variation remains a priority
for clinical genome interpretation. State-of-the-art machine learning variant prioritization tools …

Sudden cardiac death (SCD) is often associated with structural abnormalities of the heart
during autopsy. This study sought to compare the diagnostic yield of postmortem genetic …