In the amyloidogenic pathway associated with Alzheimer disease ( AD ), the amyloid precursor
protein ( APP ) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment (C99) …

The link between cholesterol homeostasis and cleavage of the amyloid precursor protein (APP),
and how this relationship relates to Alzheimer's disease (AD) pathogenesis, is still …

The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset
Alzheimer’s disease (AD). However, the reason for the association between APOE4 and AD …

The discovery of contact sites was a breakthrough in cell biology. We have learned that an
organelle cannot function in isolation, and that many cellular functions depend on …

Objective— Tissue macrophages induce and perpetuate proinflammatory responses,
thereby promoting metabolic and cardiovascular disease. Lipoprotein lipase (LpL), the rate-limiting …

Chronic alcohol consumption leads to a spectrum of liver disease that is associated with
significant global mortality and morbidity. Alcohol is known to deplete hepatic vitamin A content, …

Inter-organelle communication is a rapidly-expanding field that has transformed our
understanding of cell biology and pathology. Organelle-organelle contact sites can generate …

A focused crawler downloads web pages that are relevant to a user specified topic. The
downloaded documents are indexed with a view to optimize speed and performance in finding …

Mitochondria are responsible for the generation of ATP by oxidative phosphorylation; however,
these multifaceted organelles regulate many other key cellular functions as well, such as …

Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer’s
disease (AD) through mechanisms that remain incompletely characterized. Similar to AD, TBI …