Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial

…, L Ilardi, V Insinga, E Iosifidis, R Kalamees… - The Lancet Child & …, 2022 - thelancet.com
Background Vancomycin is the most widely used antibiotic for neonatal Gram-positive
sepsis, but clinical outcome data of dosing strategies are scarce. The NeoVanc programme …

DosOpt: a tool for personalized Bayesian dose adjustment of vancomycin in neonates

T Tasa, T Metsvaht, R Kalamees, J Vilo… - Therapeutic Drug …, 2017 - journals.lww.com
Background: Our main aim has been to design a framework to improve vancomycin dosing
in neonates. This required the development and verification of a computerized dose …

Prospective validation of a model-informed precision dosing tool for vancomycin treatment in neonates

R Kalamees, H Soeorg, ML Ilmoja… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
… © 2024 Kalamees et al. This is an open-access article distributed under the terms of … Riste
KalameesKalamees R , Soeorg H , Ilmoja M , Margus K , Lutsar I , Metsvaht T . Prospective …

Subgroup identification-based model selection to improve the predictive performance of individualized dosing

H Soeorg, R Kalamees, I Lutsar, T Metsvaht - Journal of Pharmacokinetics …, 2024 - Springer
Currently, model-informed precision dosing uses one population pharmacokinetic model that
best fits the target population. We aimed to develop a subgroup identification-based model …

Farmakokineetika alustalad arstilt arstile

R Kalamees, I Lutsar, H Soeorg, T Metsvaht - Eesti Arst, 2020 - ojs.utlib.ee
3. Arsti eesmärk on aidata ravimil n-ö vaenlase tagalasse tungida ehk arst peaks manustama
ravimit viisil, mis tagaks paratamatutest farmakokineetilistest protsessidest hoolimata …

External evaluation of population pharmacokinetic models for vancomycin in neonates

T Tasa, R Kalamees, J Vilo, I Lutsar, T Metsvaht - bioRxiv, 2018 - biorxiv.org
Introduction Numerous vancomycin population pharmacokinetic (PK) models of neonates
have been published. We aimed to comparatively evaluate a set of these models by …

Hygrothermal calculations and laboratory tests on timber-framed wall structures

T Kalamees, J Vinha - Building and Environment, 2003 - Elsevier
The purpose of the study was to test the accuracy of hygrothermal models simulating Nordic
climatic conditions from autumn to spring. The results produced by three hygrothermal …

Impact of ETICS on corrosion propagation of concrete facade

S Ilomets, T Kalamees, J Lahdensivu, P Klõšeiko - Energy Procedia, 2016 - Elsevier
… In the case of the original, uncovered wall, RH drops in spring within each year but rises
up to close to 100% due to WDR in summer and autumn. In the case of ETICS, the majority of …

Indoor humidity loads and moisture production in lightweight timber-frame detached houses

T Kalamees, J Vinha, J Kurnitski - Journal of Building …, 2006 - journals.sagepub.com
… to ž21 C at outdoor temperature Ą25 C and rises up to ž23 C at ž15 C outdoor temperature.
During summer the daily average indoor temperature rises up to ž27 C at daily average …

[CITATION][C] Personalised Bayesian Dose Adjustment of Vancomycin in Neonates

T Tasa, T Metsvaht, R Kalamees… - HUMAN …, 2016 - … ALLSCHWILERSTRASSE 10, CH …