Attentional control theory is an approach to anxiety and cognition representing a major
development of Eysenck and Calvo's (1992) processing efficiency theory. It is assumed that …

The success of mechanism-based drug discovery depends on the definition of the drug
target. This definition becomes even more important as we try to link drug response to genetic …

Functional genomics approaches can overcome limitations—such as the lack of identification
of robust targets and poor clinical efficacy—that hamper cancer drug development. Here …

ChEMBL is an open large-scale bioactivity database (https://www. ebi. ac. uk/chembl), previously
described in the 2012 Nucleic Acids Research Database Issue. Since then, a variety of …

Genome-wide association scans with high-throughput metabolic profiling provide unprecedented
insights into how genetic variation influences metabolism and complex disease. Here …

Target identification (determining the correct drug targets for a disease) and target validation
(demonstrating an effect of target perturbation on disease biomarkers and disease end …

Objective Fear of pain, which is hypothesized to result in avoidance behavior, has been
described as an obstacle to recovery in populations of patients with low back pain. However, the …

The human proteome is a major source of therapeutic targets. Recent genetic association
analyses of the plasma proteome enable systematic evaluation of the causal consequences of …

Plant cell suspension cultures have several advantages that make them suitable for the
production of recombinant proteins. They can be cultivated under aseptic conditions using …

A series of new imidazole carboxylic esters (carbamates) and N-acylimidazole derivatives
of betulin and betulinic acid (14–29) have been synthesized. The new compounds were …