We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Background : Coronary artery disease (CAD) has substantial heritability and a polygenic
architecture. However, the potential of genomic risk scores to help predict CAD outcomes has …

Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified
66 loci at'genome-wide significance'(P< 5× 10− 8) at the time of this analysis, but a much …

Background We tested whether genetic factors distinctly contribute to either development of
coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary …

Background Statin treatment and variants in the gene encoding HMG-CoA reductase are
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …

BACKGROUND: Multiple scoring systems have been devised to quantify angiographic coronary
artery disease (CAD) burden, but it is unclear how these scores relate to each other and …

Sequence variants affecting blood lipids and coronary artery disease (CAD) may enhance
understanding of the atherogenicity of lipid fractions. Using a large resource of whole-genome …

We performed a genome-wide association study on 1,292 individuals with abdominal aortic
aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up …

Objectives : The purpose of this study is investigate the effects of variants in the
apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic …

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance
of environmental and biological risk factors for disease. However, causal inference is …