Mapping the entire frequency bandwidth of brain electrophysiological signals is of paramount
importance for understanding physiological and pathological states. The ability to record …

Neocortical epilepsy is frequently drug-resistant. Surgery to remove the epileptogenic zone
is only feasible in a minority of cases, leaving many patients without an effective treatment. …

… Author links open overlay panel Robert C. … (C) Illumination of the brain slice with 10 s of
blue light results in robust AP firing (detected electrophysiologically from the patched neuron). …

Refractory focal epilepsy is a devastating disease for which there is frequently no effective
treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way …

Epilepsy represents a major burden to society, not least because approximately 25% of
patients do not respond satisfactorily to antiepileptic medication, and only a minority with …

Focal epilepsy involves excessive cortical activity that propagates both locally and distally.
Does this propagation follow the same routes as normal cortical activity? We …

Glioblastoma (GBM) is the most common and advanced form of primary malignant tumour
occurring in the adult central nervous system, and it is frequently associated with epilepsy, a …

This technical note introduces adiabatic dynamic causal modelling, a method for inferring
slow changes in biophysical parameters that control fluctuations of fast neuronal states. The …

The movement of ions in and out of neurons can exert significant effects on neighboring
cells. Here we report several experimentally important consequences of activation of the …

Objective Loss of function of the astrocyte‐specific protein MLC1 leads to the childhood‐onset
leukodystrophy “megalencephalic leukoencephalopathy with subcortical cysts” (MLC). …