We analyzed genome-wide association data from 1,380 Europeans with early-onset and
morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers …

Adipose tissue located within the abdominal cavity has been suggested to be functionally and
metabolically distinct from that of the subcutaneous compartment. These differences could …

Type 2 diabetes mellitus results from the interaction of environmental factors with a combination
of genetic variants, most of which were hitherto unknown. A systematic search for these …

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …

We have performed a genome-wide analysis of common genetic variation controlling
differential expression of transcript isoforms in the CEU HapMap population using a …

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …

To elucidate the genetic factors predisposing to AIDS progression, we analyzed a unique
cohort of 275 human immunodeficiency virus (HIV) type 1-seropositive nonprogressor patients …

Several studies have shown that healthy individuals with fasting plasma glucose (FPG) levels
at the high end of the normal range have an increased risk of mortality. To identify genetic …

Using a multistage genetic association approach comprising 7,480 affected individuals and
7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal …

Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a
major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We …