Vitamin D has long been recognized as essential to the skeletal system. Newer evidence
suggests that it also plays a major role regulating the immune system, perhaps including …

Antiretroviral treatment (ART) has transformed human immunodeficiency virus (HIV) from a
deadly disease to a chronic illness that potentially has little effect on life expectancy. Modern …

For many medically relevant viruses, there is now considerable evidence that both viral and
cellular kinases play important roles in viral infection. Ultimately, these kinases, and the …

Antistaphylococcal beta-lactams enhance daptomycin activity and have been used
successfully in combination for refractory methicillin-resistant Staphylococcus aureus (MRSA) …

P pili are highly ordered composite structures consisting of thin fibrillar tips joined end-to-end
to rigid helical rods. The production of these virulence-associated structures requires a …

Obstacles to bacterial survival and replication in the cytosol of host cells, and the mechanisms
used by bacterial pathogens to adapt to this niche are not well understood. Listeria …

Background Hepatitis C Virus (HCV) infection is a leading indication for liver transplantation.
HCV infection reoccurs almost universally post transplant, decreasing both graft longevity …

HCV reoccurs after liver transplantation and increases mortality. Cyclosporine, but not
tacrolimus, has potent antiviral effects against HCV replication in cell culture. To determine the …

Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic
factors influencing complex traits related to health and disease among minority populations. …

While β-lactam antibiotics are a critical part of the antimicrobial arsenal, they are frequently
compromised by various resistance mechanisms, including changes in penicillin binding …