Neuraxial patterning is a continuous process that extends over a protracted period of
development. During gastrulation a crude anteroposterior pattern, detectable by molecular markers…

Animal embryos need to specify different cell types, and the genetic functions that provide
such controls are easy to comprehend since they result in the formation of overtly differentiated …

Lampreys are representatives of an ancient vertebrate lineage that diverged from our own∼
500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) …

Organization and Evolution of Hox/HOM-C Complexes The genomic structural and
organizational similarities between vertebrate Hox and Drosophila HOM-C complexes provided …

In situ hybridization analysis of mouse embryos shows the seven members of the Hex-2
complex to be differentially expressed in the central and peripheral nervous system and in …

The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons
originating from different segments. We report here that members of the Hox-2 cluster of …

THE branchial region of the vertebrate head forms through complex interactions involving
rhombomeric segments, neural crest and branchial arches 1 . It is thought that aspects of their …

WITHIN the Hoxb homeobox gene complex, Hoxb-1 is the earliest member expressed in the
mesoderm and neuroectoderm of primitive streak and presomite embryos, preceding …

Spondylocostal dysostosis (SD, MIM 277300) is a group of vertebral malsegmentation
syndromes with reduced stature resulting from axial skeletal defects. SD is characterized by …

IT has been suggested that Hox genes play an important part in the patterning of limbs 1–3 ,
vertebrae 4–6 and craniofacial structures 5,7–9 by providing an ordered molecular system …