IgG FcRs are important mediators of immunity and play a key role during Ab-based
immunotherapy. Within the leukocyte IgG receptor family, only FcγRI is capable of IgG binding with …

The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is
hijacked in many pathological conditions. This affects MHC class I levels and peptide …

Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and
interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well-…

Tumor escape from immune-mediated destruction has been associated with immunosuppressive
mechanisms that inhibit T cell activation. Although evidence for an active immune …

Cancer is fueled by deregulation of signaling pathways in control of cellular growth and
proliferation. These pathways are also targeted by infectious pathogens en route to establishing …

Through a network of progressively maturing vesicles, the endosomal system connects the
cell's interior with extracellular space. Intriguingly, this network exhibits a bilateral architecture…

Antigen cross-presentation, wherein dendritic cells (DCs) present exogenous antigen on
major histocompatibility class I (MHC-I) molecules, is considered the primary mechanism by …

HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate
CD8 + T cells. This process is often hijacked by tumors and pathogens for immune evasion…

Endogenous type I IFN production after innate immune recognition of tumor cells is critical
for generating natural adaptive immune responses against tumors in vivo. We recently have …

Abstract Knowledge of the accurate copy number of HLA class I presented ligands is important
in fundamental and clinical immunology. Currently, the best copy number determinations …