Recent technological advancements have enabled the profiling of a large number of genome-wide
features in individual cells. However, single-cell data present unique challenges that …

Adoptive therapy using chimeric antigen receptor-modified T cells (CAR-T cells) is effective
in hematologic but not epithelial malignancies, which cause the greatest mortality. In breast …

Memory T cells are critical for long-term immunity against reinfection and require interleukin-7
(IL-7), but the mechanisms by which IL-7 controls memory T cell survival, particularly …

The transcription factor T-bet is critical for cytotoxic T lymphocyte (CTL) differentiation, but it
is unclear how it operates in a graded manner in the formation of both terminal effector and …

Understanding immunological memory formation depends on elucidating how multipotent
memory precursor (MP) cells maintain developmental plasticity and longevity to provide long-…

Memory CD8 + T cells are critical for host defense upon reexposure to intracellular pathogens.
We found that interleukin 10 (IL-10) derived from CD4 + regulatory T cells (T reg cells) …

CD4 + follicular regulatory T (T fr ) cells suppress B cell responses through modulation of
follicular helper T (T fh ) cells and germinal center (GC) development. We found that T fr cells …

Eliciting effective antitumor immune responses in patients who fail checkpoint inhibitor
therapy is a critical challenge in cancer immunotherapy, and in such patients, tumor-associated …

Long-term immunity depends partly on the establishment of memory CD8+ T cells. We
identified a counterregulatory network between the homologous transcription factors ZEB1 and …

A classical hallmark of acute inflammation is neutrophil infiltration of tissues, a multistep
process that involves sequential cell–cell interactions of circulating leukocytes with IL-1–or TNF-…