PTH differentially regulates expression of RANKL and OPG

…, BP Halloran, DD Bikle, RA Nissenson - Journal of Bone and …, 2004 - academic.oup.com
RANKL and OPG gene expressions were measured with and without PTH at different stages
of osteoblast development. Mouse stromal cells were cultured in osteoblast differentiating …

Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.

…, M Rosenblatt, RA Nissenson - The Journal of …, 1987 - Am Soc Clin Investig
A variety of solid tumors secrete proteins that are immunochemically distinct from parathyroid
hormone (PTH) but activate PTH-responsive adenylate cyclase. Such PTH-like proteins …

Engineering GPCR signaling pathways with RASSLs

…, WC Chang, Y Pei, KD McCarthy, RA Nissenson… - Nature …, 2008 - nature.com
We are creating families of designer G protein–coupled receptors (GPCRs) to allow for
precise spatiotemporal control of GPCR signaling in vivo. These engineered GPCRs, called …

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development

…, JD Deeds, H Kohno, RA Nissenson… - …, 1996 - academic.oup.com
To test the hypothesis that PTH-related peptide (PTHrP) is a paracrine regulator of
endochondral bone development, we localized PTHrP and its cognate receptor during normal …

High levels of a parathyroid hormone-like protein in milk.

…, JC King, D Diep, RA Nissenson… - Proceedings of the …, 1989 - National Acad Sciences
Expression of a parathyroid hormone-like protein (PLP), which is associated with hypercalcemia
in malignancy, has recently been localized to normal lactating mammary tissue. We …

Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass

…, BR Conklin, RA Nissenson - Proceedings of the …, 2008 - National Acad Sciences
Osteoblasts are essential for maintaining bone mass, avoiding osteoporosis, and repairing
injured bone. Activation of osteoblast G protein-coupled receptors (GPCRs), such as the …

Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia

AA Budayr, RA Nissenson, RF Klein… - Annals of internal …, 1989 - acpjournals.org
Study Objective: To measure the serum levels of a newly described parathyroid hormone-like
protein (PLP), which was isolated from malignant tumors associated with hypercalcemia, …

[HTML][HTML] Similar structures and shared switch mechanisms of the β2-adrenoceptor and the parathyroid hormone receptor: Zn (II) bridges between helices III and VI …

…, O Lichtarge, T Iiri, EC Meng, RA Nissenson… - Journal of Biological …, 1999 - ASBMB
The seven transmembrane helices of serpentine receptors comprise a conserved switch that
relays signals from extracellular stimuli to heterotrimeric G proteins on the cytoplasmic face …

Mitogenic Gi protein‐MAP kinase signaling cascade in MC3T3‐E1 osteogenic cells: Activation by C‐terminal pentapeptide of osteogenic growth peptide [OGP(10–14 …

…, M Namdar‐Attar, RA Nissenson… - Journal of cellular …, 2001 - Wiley Online Library
In osteogenic and other cells the mitogen‐activated protein (MAP) kinases have a key role
in regulating proliferation and differentiated functions. The osteogenic growth peptide (OGP) …

[HTML][HTML] Internalization determinants of the parathyroid hormone receptor differentially regulate β-arrestin/receptor association

…, T Bambino, MJ Lohse, RA Nissenson - Journal of Biological …, 2002 - ASBMB
β-Arrestins have been implicated in regulating internalization of the parathyroid hormone
receptor (PTHR), but the structural features in the receptor required for this effect are unknown. …