Conformational properties of α-synuclein in its free and lipid-associated states

D Eliezer, E Kutluay, R Bussell Jr, G Browne - Journal of molecular biology, 2001 - Elsevier
α-Synuclein (αS) is a presynaptic terminal protein that is believed to play an important role
in the pathogenesis of Parkinson’s disease (PD). We have used NMR spectroscopy to …

A structural and functional role for 11-mer repeats in α-synuclein and other exchangeable lipid binding proteins

R Bussell Jr, D Eliezer - Journal of molecular biology, 2003 - Elsevier
We have used NMR spectroscopy and limited proteolysis to characterize the structural
properties of the Parkinson's disease-related protein α-synuclein in lipid and detergent micelle …

Global chemical effects of the microbiome include new bile-acid conjugations

…, H Mallick, EA Franzosa, J Lloyd-Price, R Bussell… - Nature, 2020 - nature.com
A mosaic of cross-phylum chemical interactions occurs between all metazoans and their
microbiomes. A number of molecular families that are known to be produced by the microbiome …

[HTML][HTML] Residual structure and dynamics in Parkinson's disease-associated mutants of α-synuclein

R Bussell, D Eliezer - Journal of Biological Chemistry, 2001 - ASBMB
α-Synuclein (αS) is a pre-synaptic protein that has been implicated as a possible causative
agent in the pathogenesis of Parkinson's disease (PD). Two autosomal dominant missense …

Control of the activity of CAR-T cells within tumours via focused ultrasound

…, P Limsakul, L Zhu, M Allen, Y Pan, R Bussell… - Nature biomedical …, 2021 - nature.com
Focused ultrasound can deliver energy safely and non-invasively into tissues at depths of
centimetres. Here we show that the genetics and cellular functions of chimeric antigen …

Helix periodicity, topology, and dynamics of membrane‐associated α‐Synuclein

R Bussell Jr, TF Ramlall, D Eliezer - Protein Science, 2005 - Wiley Online Library
The protein α‐Synuclein (aS) is a synaptic vesicle‐associated regulator of synaptic strength
and dopamine homeostasis with a pathological role in Parkinson's disease. The normal …

Effects of Parkinson's disease-linked mutations on the structure of lipid-associated α-synuclein

R Bussell, D Eliezer - Biochemistry, 2004 - ACS Publications
α-Synuclein (αS) is a lipid-binding synaptic protein of unknown function that is found in an
aggregated amyloid fibril form in the intraneuronal Lewy body deposits that are a defining …

Adolescents who kill

…, JR Hughes, J Arbit, RE Bussell - Journal of Clinical …, 1990 - Wiley Online Library
From a sample of 1,956 adolescent delinquents referred to us by the court for physical,
psychological, psychiatric, educational, and social examinations, 71 delinquents convicted of …

[HTML][HTML] Spatial encoding in primate hippocampus during free navigation

…, SU Nummela, M Metke, GW Diehl, R Bussell… - PLoS …, 2019 - journals.plos.org
The hippocampus comprises two neural signals—place cells and θ oscillations—that contribute
to facets of spatial navigation. Although their complementary relationship has been well …

Awake mouse imaging: from two-photon microscopy to blood oxygen level–dependent functional magnetic resonance imaging

…, D Kleinfeld, T Komiyama, TT Liu, R Bussell… - Biological Psychiatry …, 2019 - Elsevier
Background Functional magnetic resonance imaging (fMRI) in awake behaving mice is well
positioned to bridge the detailed cellular-level view of brain activity, which has become …