MATERIALS AND METHODS Five male volunteers (mean age 29 years) with no history of
complaints referable to the ankle joint, and 9 patients (mean age 43 years) with unilateral, …

Models of transcription are often built around a picture of RNA polymerase and transcription
factors (TFs) acting on a single copy of a promoter. However, most TFs are shared between …

Variability in gene expression among genetically identical cells has emerged as a central
preoccupation in the study of gene regulation; however, a divide exists between the …

One of the paramount goals of synthetic biology is to have the ability to tune transcriptional
networks to targeted levels of expression at will. As a step in that direction, we have …

Biological systems must possess mechanisms that prevent inappropriate responses to
spurious environmental inputs. Caenorhabditis elegans has two breakdown pathways for the …

Gene expression is intrinsically a stochastic (noisy) process with important implications for
cellular functions. Deciphering the underlying mechanisms of gene expression noise remains …

The proteins associated with gene regulation are often shared between multiple pathways
simultaneously. By way of contrast, models in regulatory biology often assume these …

We review recent theoretical efforts that predict how line-active molecules can promote lateral
heterogeneities (or domains) in model membranes. This fundamental understanding may …

Total hip arthroplasty was done in thirty-three patients who had had previous surgical attempts
at arthrodesis of the hip. The arthrodesis had failed in nineteen patients, and the other …

Predicting the quantitative regulatory function of transcription factors (TFs) based on factors
such as binding sequence, binding location, and promoter type is not possible. The …