Background Children with high-risk neuroblastoma have a poor outcome. In this study, we
assessed whether myeloablative therapy in conjunction with transplantation of autologous …

A domain of DNA designated N-myc is amplified 20- to 140-fold in human neuroblastoma
cell lines but not in cell lines from other tumor types. N-myc has now been found to be …

Eighty-nine patients with untreated primary neuroblastomas were studied to determine the
relation between the number of copies of the N-myc oncogene and survival without disease …

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …

Purpose We assessed the long-term outcome of patients enrolled on CCG-3891, a high-risk
neuroblastoma study in which patients were randomly assigned to undergo autologous …

Neuroblastoma is one of the most common tumors in childhood. However, it often has been
difficult to compare clinical and laboratory studies of this disease due to a lack of uniform …

Background Neuroblastoma is a childhood cancer with considerable morbidity and mortality.
Tumor-derived biomarkers may improve risk stratification. Methods We screened 915 …

Purpose: The goal of this study was to determine the incidence of metastatic sites in
neuroblastoma and the extent to which metastatic sites correlate with age, tumor biology, and …

α-Galactosylceramide (αGalCer) stimulates NKT cells and has antitumor activity in mice.
Murine NKT cells may directly kill tumor cells and induce NK cell cytotoxicity, but the …

Background The survival rate among patients with intermediate-risk neuroblastoma who
receive dose-intensive chemotherapy is excellent, but the survival rate among patients who …