The circadian clock orchestrates many aspects of human physiology, and disruption of this
clock has been implicated in various pathologies, ranging from cancer to metabolic syndrome …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

The timing of daily circadian behavior can be highly variable among different individuals, and
twin studies have suggested that about half of this variability is environmentally controlled. …

Both casein kinase 1 delta (CK1δ) and epsilon (CK1ε) phosphorylate core clock proteins of
the mammalian circadian oscillator. To assess the roles of CK1δ and CK1ε in the circadian …

… Robert Dallmann Robert Dallmann … Dallmann R. …

Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …

Short-chain quinones are described as potent antioxidants and in the case of idebenone
have already been under clinical investigation for the treatment of neuromuscular disorders. …

Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative
phosphorylation and generation of ATP, are strongly clock controlled. Here we show that …

Aims/hypothesis Obese people exhibit reduced circulating peptide YY (PYY) levels, but it is
unclear whether this is a consequence or cause of obesity. We therefore investigated the …

The accumulation of adenosine is strongly correlated with the need for sleep and the detection
of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian timing …