The role of LL-37, a human cationic antimicrobial peptide, in the immune system is not yet
clearly understood. It is a widely expressed peptide that can be up-regulated during an …

The aim of broth and agar dilution methods is to determine the lowest concentration of the
assayed antimicrobial agent (minimal inhibitory concentration, MIC) that, under defined test …

Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities are
present in virtually every life form, as an important component of (innate) immune defenses…

Antibiotics have saved countless lives and enabled the development of modern medicine over
the past 70 years. However, it is clear that the success of antibiotics might only have been …

Antimicrobial host defense peptides are produced by all complex organisms as well as
some microbes and have diverse and complex antimicrobial activities. Collectively these …

Antimicrobial cationic peptides are an important component of the innate defenses of all
species of life. Different peptides may have antibacterial, antiendotoxic, antibiotic-potentiating or …

Hundreds of peptide antibiotics have been described in the past half-century (20, 28, 35).
These fall into two classes, nonribosomally synthesized peptides, such as the gramicidins, …

The era of the "classical antibiotic" may be over. The emergence of resistance has seen to
that. Yet no truly novel class of antibacterial agent has come on the market in the past 30 years…

Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

Cationic antimicrobial peptides are found in all living species. A single animal can contain >24
different antimicrobial peptides, which fall into four structural classes. These peptides are …