Background Many patients with asthma have uncontrolled disease despite treatment with
inhaled glucocorticoids. One potential cause of the variability in response to treatment is …

Background It is unknown whether inhaled corticosteroids can modify the subsequent
development of asthma in preschool children at high risk for asthma. Methods We randomly …

Rationale: Virus-induced wheezing episodes in infancy often precede the development of
asthma. Whether infections with specific viral pathogens confer differential future asthma risk …

It is increasingly clear that asthma is a complex disease made up of number of disease
variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of …

Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and
annually updated a global strategy for asthma management and prevention that has formed …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

BACKGROUND: The contribution of viral respiratory infections during infancy to the development
of subsequent wheezing and/or allergic diseases in early childhood is not established. …

Viral respiratory tract infections are common and usually selflimited illnesses. For patients at
risk of asthma, or with existing asthma, viral respiratory tract infections can have a profound …

BACKGROUND: Responses to inhaled corticosteroids (ICSs) and leukotriene receptor
antagonists (LTRAs) vary among asthmatic patients. OBJECTIVE: We sought to determine …

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