Introduction Plummeting sequencing costs have led to a great increase in the number of
personal genomes. Interpreting the large number of variants in them, particularly in noncoding …

We present Interactome INSIDER, a tool to link genomic variant information with structural
protein–protein interactomes. Underlying this tool is the application of machine learning to …

Here, we present FissionNet, a proteome-wide binary protein interactome for S. pombe,
comprising 2,278 high-quality interactions, of which ∼50% were previously not reported in any …

Maintaining wild type protein–protein interactions is essential for the normal function of cell
and any mutation that alter their characteristics can cause disease. Therefore, the ability to …

Identifying disease-associated missense mutations remains a challenge, especially in large-scale
sequencing studies. Here we establish an experimentally and computationally …

Each human genome carries tens of thousands of coding variants. The extent to which this
variation is functional and the mechanisms by which they exert their influence remains largely …

Understanding the functional relevance of DNA variants is essential for all exome and genome
sequencing projects. However, current mutagenesis cloning protocols require Sanger …

Embryonic aneuploidy from mis-segregation of chromosomes during meiosis causes
pregnancy loss. Proper disjunction of homologous chromosomes requires the mismatch repair (…

Motivation Vast majority of human genetic disorders are associated with mutations that affect
protein–protein interactions by altering wild-type binding affinity. Therefore, it is extremely …

The study of the molecular basis of human disease has gained increasing attention over the
past decade. With significant improvements in sequencing efficiency and throughput, a …