The vascular smooth muscle cells of coronary arteries are distinguished from those of the
proximal aorta by a number of structural and functional criteria which may include an increased …

The epicardium and dorsal mesocardium are known to be the source of structures that form
the wall of the coronary vessels. Because mouse knockout studies have shown that proper …

Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to better …

Regulation of gap junction (GJ) organization is critical for proper function of excitable tissues
such as heart and brain, yet mechanisms that govern the dynamic patterning of GJs remain …

Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

Fibrotic scars deposited during skin wound healing can cause disfiguration and loss of dermal
function. Scar differentiation involves inputs from multiple cell types in a predictable and …

Connexin 43 (Cx43) is a gap junction (GJ) protein widely expressed in mammalian tissues
that mediates cell-to-cell coupling. Intercellular channels comprising GJ aggregates form from …

Nonuniformity in the spatial patterning of gap junctions between heart muscle cells is now
recognized as an important determinant of electromechanical function in working myocardium. …

Zebrafish and Xenopus have become popular model organisms for studying vertebrate
development of many organ systems, including the heart. However, it is not clear whether the …

Electrical coupling between heart muscle cells is mediated by specialised regions of
sarcolemmal interaction termed gap junctions. In previous work, we have demonstrated that …