Background Nivolumab plus ipilimumab produced objective responses in patients with
advanced renal-cell carcinoma in a pilot study. This phase 3 trial compared nivolumab plus …

Background Pazopanib and sunitinib provided a progression-free survival benefit, as compared
with placebo or interferon, in previous phase 3 studies involving patients with metastatic …

Purpose Pazopanib is an oral angiogenesis inhibitor targeting vascular endothelial growth
factor receptor, platelet-derived growth factor receptor, and c-Kit. This randomized, double-…

Antibody fragments of predetermined binding specificity have recently been constructed from
repertoires of antibody V genes, bypassing hybridoma technology and even immunization. …

Background The combination of pembrolizumab and axitinib showed antitumor activity in a
phase 1b trial involving patients with previously untreated advanced renal-cell carcinoma. …

One of the major limitations in the use of genetically modified mice for studying cognitive
functions is the lack of regional and temporal control of gene function. To overcome these …

Background A phase 2 trial showed improved progression-free survival for atezolizumab plus
bevacizumab versus sunitinib in patients with metastatic renal cell carcinoma who express …

Although long-term potentiation (LTP) in the CA1 region of the hippocampus is initiated
postsynaptically by the influx of Ca2+ through N-methyl-D-aspartate receptor channels, the …

‘Tailoring’ refers to any of a number of methods for creating communications individualized
for their receivers, with the expectation that this individualization will lead to larger intended …

We describe a process, based on display of antibodies on the surface of filamentous
bacteriophage, for selecting antibodies either by their affinity for antigen or by their kinetics of …