Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships 1 , 2 . …

Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However,
which of the myriad of detected AS events provide important biological functions is not well …

Traditionally, protein–protein interactions were thought to be mediated by large, structured
domains. However, it has become clear that the interactome comprises a wide range of …

An average shotgun proteomics experiment detects approximately 10,000 human proteins
from a single sample. However, individual proteins are typically identified by peptide …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to mediate
the functions required for cell viability. Specific, context-dependent and tightly controlled …

Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide
low-affinity interaction interfaces. These compact modules play central roles in mediating …

The eukaryotic linear motif (ELM http://elm.eu.org ) resource is a hub for collecting, classifying
and curating information about short linear motifs (SLiMs). For >10 years, this resource has …

Linear motifs are short segments of multidomain proteins that provide regulatory functions
independently of protein tertiary structure. Much of intracellular signalling passes through …

Networks of coordinated alternative splicing (AS) events play critical roles in development
and disease. However, a comprehensive knowledge of the factors that regulate these …