We have demonstrated the existence of two distinct subtypes of the angiotensin II receptor
in the rat adrenal gland using radioligand binding and tissue section autoradiography. The …

A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor
activity against L1210 leukemia and B16 melanoma in the National Cancer Institute's …

Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine
phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic …

Hepatic cystogenesis in polycystic liver disease is associated with increased levels of cyclic
adenosine monophosphate (cAMP) in cholangiocytes lining liver cysts. Takeda G protein …

TNF-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent because it
shows apoptosis-inducing activity in transformed, but not in normal, cells. As with most …

A series of novel, potent antagonists of the inhibitor of apoptosis proteins (IAPs) were
synthesized in a highly convergent and rapid fashion (≤6 steps) using the Ugi four-component …

Specific retinoid X receptor (RXR) agonists, such as LG100268 (LG268), and the thiazolidinedione
(TZD) PPARγ agonists, such as rosiglitazone, produce insulin sensitization in rodent …

A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-α/γ
agonist, LY465608, was designed to address the major metabolic disturbances of type 2 …

Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed
throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors …

Treatment of inflammation is often accomplished through the use of glucocorticoids. However,
their use is limited by side effects. We have examined the activity of a novel glucocorticoid …