Ribonucleases H are enzymes that cleave the RNA of RNA/DNA hybrids that form during
replication and repair and which could lead to DNA instability if they were not processed. There …

RNase H belongs to a nucleotidyl-transferase superfamily, which includes transposase,
retroviral integrase, Holliday junction resolvase, and RISC nuclease Argonaute. We report the …

Selenomethionyl Protein Page 1 agreement with the data for the Great Red Spot and the
White Oval BC on Jupiter lends support to our application of these simple models to the Great …

The delivery of soluble hydrolases to lysosomes is mediated by the cation-independent and
cation-dependent mannose 6-phosphate receptors. The cytosolic tails of both receptors …

Although ribonucleases H (RNases H) have long been implicated in DNA metabolism, they
are not required for viability in prokaryotes or unicellular eukaryotes. We generated Rnaseh1 …

Ribonucleotides are incorporated into DNA by the replicative DNA polymerases at frequencies
of about 2 per kb, which makes them by far the most abundant form of potential DNA …

We report here crystal structures of human RNase H1 complexed with an RNA/DNA substrate.
Unlike B. halodurans RNase H1, human RNase H1 has a basic protrusion, which forms a …

Previous biochemical studies have suggested a role for bacterial DNA topoisomerase (TOPO)
I in the suppression of R-loop formation during transcription. In this report, we present …

High-throughput screening of a National Cancer Institute library of pure natural products
identified the hydroxylated tropolone derivatives β-thujaplicinol (2,7-dihydroxy-4-1(methylethyl)-…

The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops
from mutations in genes encoding several nucleotide-processing proteins, including RNase …