Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural
GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy …

Brain malignancies encompass a range of primary and metastatic cancers, including low-grade
and high-grade gliomas and brain metastases (BrMs) originating from diverse …

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity
back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset …

Myeloid malignancies, including acute myeloid leukaemia (AML), arise from the expansion
of haematopoietic stem and progenitor cells that acquire somatic mutations. Bulk molecular …

We are currently living in the “genomic era.” In the last decade, high-throughput genomic
analyses have generated massive quantities of data that can be used to explore gene function …

INTRODUCTION Therapies targeted against the tumor microenvironment (TME) represent a
promising approach for treating cancer. This appeal arises in part from the decreased …

Extensive transcriptional and ontogenetic diversity exists among normal tissue-resident
macrophages, with unique transcriptional profiles endowing the cells with tissue-specific …

Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood
cells with one or more somatic mutations. Individuals with CH are at greater risk for …

Metastasis remains the most common cause of death in most cancers, with limited therapies
for combating disseminated disease. While the primary tumour microenvironment is an …

Three new techniques to produce a continuous counter-current liquid phase flow in the
absence of a solid support show a high efficiency in solute partitioning. The first uses a coiled …