Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

10.7554/eLife.39702.001 Genetic predictions of height differ among human populations
and these differences have been interpreted as evidence of polygenic adaptation. These …

Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …

Genomic prediction has the potential to contribute to precision medicine. However, to date,
the utility of such predictors is limited due to low accuracy for most traits. Here theory and …

Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to …

Background Antidepressants are a first-line treatment for depression. However, only a third
of individuals experience remission after the first treatment. Common genetic variation, in part…

The relative contributions of genetics and environment to temporal and geographic variation
in human height remain largely unknown. Ancient DNA has identified changes in genetic …

Human culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000
y BP This shift is hypothesized to have resulted in increased individual fitness and …

When asked to translate utterances, people might merely make sure that their translations
have the same meaning as the source, but they might also maintain aspects of sentence form …

Background The prevalence of depression is higher in individuals with autoimmune diseases,
but the mechanisms underlying the observed comorbidities are unknown. Shared genetic …