Cytosine residues in the sequence 5′CpG (cytosine–guanine) are often postsynthetically
methylated in animal genomes. CpG methylation is involved in long-term silencing of certain …

The myc protooncogene family has been implicated in cell proliferation, differentiation, and
neoplasia, but its mechanism of function at the molecular level is unknown. The carboxyl …

▪ Abstract The Myc/Max/Mad network comprises a group of transcription factors whose distinct
interactions result in gene-specific transcriptional activation or repression. A great deal of …

Transcriptional repression by Mad–Max heterodimers requires interaction of Mad with the
corepressors mSin3A/B. Sin3p, the S. cerevisiae homolog of mSin3, functions in the same …

The role of the myc gene family in the biology of normal and cancer cells has been intensively
studied since the early 1980s. myc genes, responding to diverse external and internal …

While it has been known for some time that the c-Myc protein binds to random DNA sequences,
no sequence-specific binding activity has been detected. At its carboxyl terminus, c-Myc …

Transcriptional repression by nuclear receptors has been correlated to binding of the
putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad …

MYC affects normal and neoplastic cell proliferation by altering gene expression, but the
precise pathways remain unclear. We used oligonucleotide microarray analysis of 6,416 genes …

Myc proteins regulate cell growth and division and are implicated in a wide range of human
cancers. We show here that Fbw7, a component of the SCF Fbw7 ubiquitin ligase and a …

Myc family proteins appear to function through heterodimerization with the stable, conatitutively
expressed bHLH-Zip protein, Max. To determine whether Max mediates the function of …