Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
…, C Rocchi, X Zhou, M Luhr, KJ Hijlkema, RP Coppes… - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …
sequestered by phagophores, which mature into autophagosomes, and then delivered into …
[HTML][HTML] Rescue of salivary gland function after stem cell transplantation in irradiated glands
…, WH Visser, HH Kampinga, G de Haan, RP Coppes - PloS one, 2008 - journals.plos.org
Head and neck cancer is the fifth most common malignancy and accounts for 3% of all new
cancer cases each year. Despite relatively high survival rates, the quality of life of these …
cancer cases each year. Despite relatively high survival rates, the quality of life of these …
Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
…, PC Fox, LS Elting, JA Langendijk, RP Coppes… - International Journal of …, 2010 - Elsevier
The most significant long-term complication of radiotherapy in the head-and-neck region is
hyposalivation and its related complaints, particularily xerostomia. This review addresses the …
hyposalivation and its related complaints, particularily xerostomia. This review addresses the …
[PDF][PDF] Long-term in vitro expansion of salivary gland stem cells driven by Wnt signals
Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renewal
ability of stem cells is dependent on extrinsic niche signals that have not been …
ability of stem cells is dependent on extrinsic niche signals that have not been …
Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer
…, JA Langendijk, J Wu, RP Coppes - Science translational …, 2015 - science.org
Each year, 500,000 patients are treated with radiotherapy for head and neck cancer, resulting
in relatively high survival rates. However, in 40% of patients, quality of life is severely …
in relatively high survival rates. However, in 40% of patients, quality of life is severely …
[HTML][HTML] Regeneration of irradiated salivary glands with stem cell marker expressing cells
…, M Van Der Zwaag, RP Van Os, RP Coppes - Radiotherapy and …, 2011 - Elsevier
BACKGROUND: Stem cell therapy could be a potential way for reducing radiation-induced
hyposalivation and improving the patient’s quality of life. However, the identification and …
hyposalivation and improving the patient’s quality of life. However, the identification and …
Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation
…, MA Stokman, R van Os, RP Coppes - Radiotherapy and …, 2009 - Elsevier
BACKGROUND: Recently, we showed that transplantation of 100–300 c-Kit + stem cells
isolated from cultured salispheres ameliorates radiation-damage in murine salivary glands. The …
isolated from cultured salispheres ameliorates radiation-damage in murine salivary glands. The …
[PDF][PDF] Purification and ex vivo expansion of fully functional salivary gland stem cells
Hyposalivation often leads to irreversible and untreatable xerostomia. Salivary gland (SG)
stem cell therapy is an attractive putative option to salvage these patients but is impeded by …
stem cell therapy is an attractive putative option to salvage these patients but is impeded by …
Concise review: Adult salivary gland stem cells and a potential therapy for xerostomia
The ability to speak, swallow, masticate, taste food, and maintain a healthy oral cavity is
heavily reliant on the presence of saliva, the hugely important effect of which on our everyday …
heavily reliant on the presence of saliva, the hugely important effect of which on our everyday …
Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands
…, T Kok, HH Kampinga, G dehaan, RP Coppes - Clinical Cancer …, 2006 - AACR
Purpose: One of the major reasons for failure of radiotherapeutic cancer treatment is the
limitation in dose that can be applied to the tumor because of coirradiation of the normal healthy …
limitation in dose that can be applied to the tumor because of coirradiation of the normal healthy …