Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

…, C Rocchi, X Zhou, M Luhr, KJ Hijlkema, RP Coppes… - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …

[HTML][HTML] Rescue of salivary gland function after stem cell transplantation in irradiated glands

…, WH Visser, HH Kampinga, G de Haan, RP Coppes - PloS one, 2008 - journals.plos.org
Head and neck cancer is the fifth most common malignancy and accounts for 3% of all new
cancer cases each year. Despite relatively high survival rates, the quality of life of these …

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers

…, PC Fox, LS Elting, JA Langendijk, RP Coppes… - International Journal of …, 2010 - Elsevier
The most significant long-term complication of radiotherapy in the head-and-neck region is
hyposalivation and its related complaints, particularily xerostomia. This review addresses the …

[PDF][PDF] Long-term in vitro expansion of salivary gland stem cells driven by Wnt signals

…, H Clevers, G De Haan, R Van Os, RP Coppes - Stem cell reports, 2016 - cell.com
Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renewal
ability of stem cells is dependent on extrinsic niche signals that have not been …

Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer

…, JA Langendijk, J Wu, RP Coppes - Science translational …, 2015 - science.org
Each year, 500,000 patients are treated with radiotherapy for head and neck cancer, resulting
in relatively high survival rates. However, in 40% of patients, quality of life is severely …

[HTML][HTML] Regeneration of irradiated salivary glands with stem cell marker expressing cells

…, M Van Der Zwaag, RP Van Os, RP Coppes - Radiotherapy and …, 2011 - Elsevier
BACKGROUND: Stem cell therapy could be a potential way for reducing radiation-induced
hyposalivation and improving the patient’s quality of life. However, the identification and …

Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation

…, MA Stokman, R van Os, RP Coppes - Radiotherapy and …, 2009 - Elsevier
BACKGROUND: Recently, we showed that transplantation of 100–300 c-Kit + stem cells
isolated from cultured salispheres ameliorates radiation-damage in murine salivary glands. The …

[PDF][PDF] Purification and ex vivo expansion of fully functional salivary gland stem cells

…, C Rocchi, E Zwart, G De Haan, R Van Os, RP Coppes - Stem cell reports, 2014 - cell.com
Hyposalivation often leads to irreversible and untreatable xerostomia. Salivary gland (SG)
stem cell therapy is an attractive putative option to salvage these patients but is impeded by …

Concise review: Adult salivary gland stem cells and a potential therapy for xerostomia

S Pringle, R Van Os, RP Coppes - Stem cells, 2013 - academic.oup.com
The ability to speak, swallow, masticate, taste food, and maintain a healthy oral cavity is
heavily reliant on the presence of saliva, the hugely important effect of which on our everyday …

Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands

…, T Kok, HH Kampinga, G dehaan, RP Coppes - Clinical Cancer …, 2006 - AACR
Purpose: One of the major reasons for failure of radiotherapeutic cancer treatment is the
limitation in dose that can be applied to the tumor because of coirradiation of the normal healthy …