Enhanced permeability and retention (EPR) and the (over-) expression of angiogenesis-related
surface receptors are key features of tumor blood vessels. As a consequence, EPR-…

The efficacy of vaccine adjuvants such as Toll-like receptor agonists (TLRa) can be improved
through formulation and delivery approaches. Here, we attached small molecule TLR-7/8a …

Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized
polymeric drug carriers that are being broadly implemented in the delivery of …

Identifying intended or accidental cellular targets for drug delivery systems is highly relevant
for evaluating therapeutic and toxic effects. However, limited knowledge exists on the …

Multidrug resistance (MDR) reduces the efficacy of chemotherapy. Besides inducing the
expression of drug efflux pumps, chemotherapy treatment alters the composition of the tumor …

Nanomedicines are sub-micrometer-sized carrier materials designed to improve the
biodistribution of iv administered (chemo-) therapeutic agents. In recent years, ever more efforts in …

The Enhanced Permeability and Retention (EPR) effect is extensively used in drug delivery
research. Taking into account that EPR is a highly variable phenomenon, we have here set …

Rationale: The blood-brain barrier (BBB) is a major obstacle for drug delivery to the brain.
Sonopermeation, which relies on the combination of ultrasound and microbubbles, has …

To tailor cell–surface interactions, precise and controlled attachment of cell‐adhesive motifs
is required, while any background non‐specific cell and protein adhesion has to be blocked …

Tumors are characterized by leaky blood vessels, and by an abnormal and heterogeneous
vascular network. These pathophysiological characteristics contribute to the enhanced …