Electric Cell-substrate Impedance Sensing (ECIS) is an in vitro impedance measuring system
to quantify the behavior of cells within adherent cell layers. To this end, cells are grown in …

Rationale: Pulmonary arterial hypertension (PAH) is a degenerative arteriopathy that leads
to right ventricular (RV) failure. BRD4 (bromodomain-containing protein 4), a member of the …

Rationale: Altered pulmonary hemodynamics and fluid flow–induced high shear stress (HSS)
are characteristic hallmarks in the pathogenesis of pulmonary arterial hypertension (PAH). …

Background: The beneficial effects of parasympathetic stimulation have been reported in left
heart failure, but whether it would be beneficial for pulmonary arterial hypertension (PAH) …

Pulmonary arterial hypertension (PAH) in congenital cardiac shunts can be reversed by
hemodynamic unloading (HU) through shunt closure. However, this reversibility potential is lost …

Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes
right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like …

Aims Endothelial cells (ECs) control vascular permeability by forming a monolayer that is
sealed by extracellular junctions. Various mediators modulate the endothelial barrier by acting …

Rationale: von Willebrand factor (vWF) mediates platelet adhesion during thrombosis. While
chronic thromboembolic pulmonary hypertension (CTEPH) is associated with increased …

Cardiovascular pathology is often accompanied by changes in relative content and/or ratios
of structural extracellular matrix (ECM) proteins within the heart and elastic vessels. Three of …

In the present study, we tested the hypothesis that chronic inflammation and oxidative/nitrosative
stress induce caveolin 1 (Cav-1) degradation, providing an underlying mechanism of …