Data independent acquisition (DIA) mass spectrometry is a powerful technique that is
improving the reproducibility and throughput of proteomics studies. Here, we introduce an …

Triple-negative breast cancer is a heterogeneous disease characterized by poor clinical
outcomes and a shortage of targeted treatment options. To discover molecular features of triple-…

Obesity is a health problem affecting more than 40% of US adults and 13% of the global
population. Anti-obesity treatments including diet, exercise, surgery and pharmacotherapies …

Systematic approaches to studying cellular signaling require phosphoproteomic techniques
that reproducibly measure the same phosphopeptides across multiple replicates, conditions, …

The coordinated regulation of protein kinases is a rapid mechanism that integrates diverse
cues and swiftly determines appropriate cellular responses. However, our understanding of …

Lipid deposition in the liver is associated with metabolic disorders including fatty liver
disease, type II diabetes, and hepatocellular cancer. The enzymes acetyl-CoA carboxylase 1 (…

Proteins can be phosphorylated at neighboring sites resulting in different functional states,
and studying the regulation of these sites has been challenging. Here we present Thesaurus, …

Lipin 2 is a phosphatidic acid phosphatase (PAP) responsible for the penultimate step of
triglyceride synthesis and dephosphorylation of phosphatidic acid (PA) to generate …

Objective To identify obesity-related cancer genes in endometrial and adipose tissue depots
of body mass index–matched morbidly obese women with and without endometrial cancer. …

The adipocyte is a key regulator of mammalian metabolism. To advance our understanding
of this important cell, we have used quantitative proteomics to define the protein composition …