Systemic lidocaine to improve quality of recovery after laparoscopic bariatric surgery: a randomized double-blinded placebo-controlled trial

…, K Duncan, P Fitzgerald, A Nader, RW Gould… - Obesity surgery, 2014 - Springer
Background Few multimodal strategies to minimize postoperative pain and improve recovery
have been examined in morbidly obese patients undergoing laparoscopic bariatric surgery…

Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

…, TM Bridges, D Dencker, RW Gould… - ACS chemical …, 2014 - ACS Publications
Positive allosteric modulators (PAMs) of the M 4 muscarinic acetylcholine receptor (mAChR)
represent a novel approach for the treatment of psychotic symptoms associated with …

[PDF][PDF] Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents

…, RL Collier, M Bubser, MT Nedelcovych, RW Gould… - Neuron, 2015 - cell.com
Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor
subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate …

Relationship Between Social Rank and Cortisol and Testosterone Concentrations in Male Cynomolgus Monkeys (Macaca fascicularis)

PW Czoty, RW Gould, MA Nader - Journal of …, 2009 - Wiley Online Library
In nonhuman primate social groups, biological differences related to social status have
proven useful for investigating the mechanisms of sensitivity to various disease states. …

Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement

…, PW Czoty, NV Riddick, HD Gage, RW Gould… - Biological …, 2012 - Elsevier
BACKGROUND: Brain imaging and behavioral studies suggest an inverse relationship
between dopamine (DA) D2/D3 receptors and vulnerability to cocaine abuse, although most …

Standardizing care for high-risk patients in spine surgery: the Northwestern high-risk spine protocol

RJ Halpin, PA Sugrue, RW Gould, PG Kallas… - Spine, 2010 - journals.lww.com
Study Design. Review article of current literature on the preoperative evaluation and postoperative
management of patients undergoing high-risk spine operations and a presentation of …

Positron emission tomography imaging studies of dopamine receptors in primate models of addiction

MA Nader, PW Czoty, RW Gould… - … Transactions of the …, 2008 - royalsocietypublishing.org
Animal models have provided valuable information related to trait and state variables
associated with vulnerability to drug addiction. Our brain imaging studies in monkeys have …

Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

RW Gould, D Dencker, M Grannan… - ACS chemical …, 2015 - ACS Publications
The M 1 muscarinic acetylcholine receptor (mAChR) subtype has been implicated in the
underlying mechanisms of learning and memory and represents an important potential …

Development and validation of a generalizable model for predicting major transfusion during spine fusion surgery

…, C Zeeni, NC Moreland, RW Gould… - Journal of …, 2014 - journals.lww.com
Background: Surgery for posterior spine instrumentation often requires major transfusion.
The aim of this study was to develop and test the validity of a model for predicting …

[HTML][HTML] Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot

…, CB Bergmann, MD Goodman, RW Gould… - JCI insight, 2024 - ncbi.nlm.nih.gov
BACKGROUND Sepsis remains a major clinical challenge for which successful treatment
requires greater precision in identifying patients at increased risk of adverse outcomes …