CTCF (CCCTC-binding factor) binds sites around the mouse β-globin locus that spatially
cluster in the erythroid cell nucleus. We show that both conditional deletion of CTCF and …

Three-dimensional organization of a gene locus is important for its regulation, as recently
demonstrated for the β-globin locus. When actively expressed, the cis-regulatory elements of …

Transcriptional activation in higher eukaryotes frequently involves the long‐range action of a
number of regulatory DNA elements. One of the main questions in transcriptional regulation …

Eukaryotic transcription can be regulated over tens or even hundreds of kilobases. We
show that such long-range gene regulation in vivo involves spatial interactions between …

Efficient transcription of genes requires a high local concentration of the relevant trans-acting
factors. Nuclear compartmentalization can provide an effective means to locally increase …

Pigmentation of skin, eye, and hair reflects some of the most evident common phenotypes in
humans. Several candidate genes for human pigmentation are identified. The SNP …

One of the complexes formed by the hematopoietic transcription factor Gata1 is a complex
with the Ldb1 (LIM domain-binding protein 1) and Tal1 proteins. It is known to be important for …

The key haematopoietic regulator Myb is essential for coordinating proliferation and differentiation.
ChIP‐Sequencing and Chromosome Conformation Capture (3C)‐Sequencing were …

Chromosome conformation capture (3C) technology is a powerful and increasingly popular
tool for analyzing the spatial organization of genomes. Several 3C variants have been …

A relationship exists between nuclear architecture and gene activity and it has been
proposed that the activity of ongoing RNA polymerase II transcription determines genome …